Effects of brief exposure to loud music on otoacoustic emissions and auditory brainstem responses
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20192614Keywords:
Hidden hearing loss, Synaptotpathy, ABR, MusicAbstract
Background: Research on noise induced hearing loss pathophysiology has recently focused on synapses rather than outer hair cells, following relevant evidence from animal studies. Findings from human studies, mainly targeting on effect of chronic exposure are controversial. Aim of this study is to investigate the immediate effect of noise exposure to synaptic function with use of ABR and DPOAEs.
Methods: Ten participants with normal hearing levels underwent DP-gram between 1 and 6 KHz and ABR at 90dB and click rates 33/sec and 44/sec before and after exposure to standardized music. Four of them were professional musicians and six were controls. Material for reliable and constant exposure to music was created, consisting of 56 wav files with music with a total duration of 2.5 hours. Files were presented in stable dB SPL levels and absolute control of dB SPL levels to ear phones was ensured. Subjects were asked to listen to music of their preference in maximum for 30 minutes. Patients exceeding 83 dB SPL maximum comfortable levels were eligible for the study.
Results: Statistically significant differences were observed before and after exposure to music for all SNRs from 1.5 to 6 KHz. Changes were similar between musicians and non-musicians. No differences were observed in ABR latencies and amplitudes in any of the waveforms before and after noise exposure.
Conclusions: A reliable technique has been developed for standardized exposure to loud sounds in humans, which can be used in future studies. Exposure to music induced decrease in DPOAE SNRs.
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References
WHO. WHO. Deafness and hearing loss. Fact sheet N°300. 2014: 1–5.
Wirtz V. Priority medicines for Europe and the World: setting a public-health-based medicines development agenda. J Pharma Policy Practice. 2015;8(1):4.
WHO ‐ World Health Organization. The World Health Report. Chapter 4. Selected occupational risks, 2002. Available at: www.who.int/ wht/2002/chapter 4/en/index8.html. Accessed on 2 March 2019.
Nelson DI, Nelson RY, Concha‐Barrientos M, Fingerhut M. The global burden of occupational noise‐induced hearing loss. Am J Industrial Med. 2005;48(6):446‐58.
Ryan AF, Kujawa SG, Hammill T, Le Prell C, Kil J. Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations. Otol Neurotol. 2016;37(8):271-5.
Lonsbury-Martin B, Martin G, Bohne B. Repeated TTS exposures in monkeys: alterations in hearing, cochlear structure, and single-unit thresholds. J Acoust Soc Am. 1987;81:1507-18.
Finneran JJ. Noise-induced hearing loss in marine mammals: A review of temporary threshold shift studies from 1996 to 2015. J Acoust Soc Am. 2015;138(3):1702-26
Kujawa SW, Liberman MC. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J Neurosci. 2009;29(45):14077-85.
Lobarinas E, Salvi R, Ding D. Insensitivity of the audiogram to carboplatin induced inner hair cell loss in chinchillas. Hear Res. 2013;302:113–20.
Schaette R, McAlpine D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J Neurosci. 2011;31(38):13452–7.
Hickox A, Larsen E, Heinz M, Shinobu L, Whitton J. Translational issues in cochlear synaptopathy. Hear Res. 2017;349:164-71.
Kujawa SW, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006;26(7):2115-23.
Costalupes, J, Young, E., Gibson, D. Effects of continuous noise backgrounds on rate response of auditory nerve fibers in cat. J Neurophysiol. 1984;51:1326-44.
Sergeyenko, Y, Lall, K, Liberman, MC, Kujawa, SW. Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J. Neurosci. 2013;33(34):1.
Fernandez K., Jeffers P., Lall K., Liberman MC, Kujawa SW. Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. J Neurosci. 2015;35(19):7509-20.
Barbee C, James J, Park J, Smith E, Johnson C, Clifton S et al. Effectiveness of Auditory Measures for Detecting Hidden Hearing Loss and/or Cochlear Synaptopathy: A Systematic Review. Semin Hear. 2018;39(2):172-209.
Bramhall N, Beach E, Epp B, Le Prell CG, Lopez-Poveda E, Plack C, et al. The search for noise-induced cochlear synaptopathy in humans: Mission impossible? Hear Res. 2019;377:88-103.
Bramhall, NF, Konrad-Martin, D, McMillan, Griest S. Auditory brainstem response altered in humans with noise exposure despite normal outer hair cell function. Ear Hear. 2017;38(1):1-12.
Bharadwaj HM, Masud S, Mehraei G, Verhulst S, Shinn-Cunningham BG. Individual differences reveal correlates of hidden hearing deficits. J Neurosci. 2015;35(5):2161-72.
Stamper, GC, Johnson TA. Auditory function in normal-hearing, noise exposed human ears. Ear Hear. 2015;36:172-84.
Valderrama JT, Beach EF, Yeend I, Sharma M, Van Dun B, Dillon H. Effects of lifetime noise exposure on the middle-age human auditory brainstem response, tinnitus and speech-in-noise intelligibility. Hear Res. 2018;365:36-48.
Ridley CL, Kopun JG, Neely ST, Gorga MP, Rasetshwane DM. Using Thresholds in Noise to Identify Hidden Hearing Loss in Humans. Ear Hear. 2018;39(5):829-44.
Prendergast G, Guest H, Munro KJ, Kluk K, Léger A, Hall DA et al. Effects of noise exposure on young adults with normal audiograms I: Electrophysiology. Hear Res. 2017;344:68-81.
Prendergast G, Tu W, Guest H, Millman RE, Kluk K, Couth S, et al. Supra-threshold auditory brainstem response amplitudes in humans: Test-retest reliability, electrode montage and noise exposure. Hear Res. 2018;364:38-47.
Liberman MC, Epstein MJ, Cleveland SS, Wang H, Maison SF. Toward a Differential Diagnosis of Hidden Hearing Loss in Humans. PLoS One. 2016;11(9):e0162726.
Verhulst S, Jagadeesh A, Mauermann M, Ernst F. Individual Differences in Auditory Brainstem Response Wave Characteristics: Relations to Different Aspects of Peripheral Hearing Loss. Trends Hear. 2016;20.
Guest H, Munro KJ, Prendergast G, Howe S, Plack CJ. Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy. Hear Res. 2017;344:265-74.
