Sino nasal melanoma of nasal cavity: a case report
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20191753Keywords:
Sino nasal melanoma, Melanin, Hemosiderin, Blue cell tumourAbstract
Sino-nasal melanoma is a rare, recurrent aggressive tumour among head and neck cancers. Nasal obstruction and recurrent, painless epistaxis are commonly reported symptoms seen in old aged individuals. The symptoms are non-specific and tend to delay the diagnosis resulting in poor prognosis. We report 80 year old male patient who presented with recurrent, painless epistaxis from the left nasal cavity with nasal obstruction. Anterior rhinoscopic examination revealed bluish black proliferative bleeding mass completely filling left nasal cavity. Contrast enhanced computed tomography showed a polypoidal soft tissue attenuation with heterogeneous enhancement completely filling left nasal cavity. Patient underwent endoscopic excision. Histopathology of specimen showed small round blue cell tumour, suggestive of sino nasal melanoma. S100 and HMB 45 were found to be positive on immunohistochemistry. Patient was then subjected to chemoradiation. No evidence of recurrence till date.
Metrics
References
Rosai J. Respiratory tract. In: Rosai J, ed. Ackerman's Surgical Pathology. 8th ed. St Louis, Mo: Mosby-Year Book Inc; 1996: 301-302.
Zak FG, Lawson W. The presence of melanocytes in the nasal cavity. Annals Otol Rhinol Laryngol. 1974;83:515-9.
Sil A, Chatrath P, Warwick-Brown. Malignant melanoma of the nose. Indian J Otolaryngol Head Neck Surg. 2004;56:59-62.
Wenig BM. Tumors of the upper respiratory tract, Part A- Nasal cavity, paranasal sinuses and nasopharynx. In: Fletcher CD, editor. Diagnostic histopathology of tumors. Vol 1. 3rd ed. Elsevier: Churchill Livingstone. 2007: 83-149.
Fu YS, Perzin KH. The nasal cavity, paranasal sinuses and nasopharynx. In: Silverberg SG, Delellis RA, Frable WJ. editors. Principles and practice of Surgical Pathology and cytopathology. Vol 2. 3rd edition. New York: Churchill Livingstone; 1997: 1039-1071.
Wenig BM, Prasad ML, Dulguerov P, Fanburg JC, Kapadia SB, Thomson LD. Neuroectodermal tumors. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. WHO classification of tumors. Pathology and Genetics, Head and Neck Tumors. Lyon: IARC Press; 2005: 65-75.
The manual for AJCC cancer staging system 8th edition. 2018.
Viswanathan N, Khanna A. Skeletal Muscle Metastasis from Malignant Melanoma. Br J Plast Surg. 2005;58:855-8.
Joshi PV, Lele VR, Aland NJ, Bhat G, Ajinkya SP, Patel RP. Malignant amelanotic melanoma - A diagnostic surprise: Flurodeoxyglocose positron emission tomography-Computed tomography and immunohistochemistry clinch the 'final diagnosis'. J Can Res Ther. 2012;8:451-3
Kato T, Takematsu H, Tomita Y, Takahashi M, Abe R. Malignant Melanoma of Mucous Membranes A Clinicopathologic Study of 13 Cases in Japanese Patients. Arch Dermatol. 1987;123(2):216–20.
Alves ISS, Berriel LGS, Alves RT, Pinto MB, Oliveira CFP, Cazzotto AC, et al. Sinonasal Melanoma: A Case Report and Literature Review. Case Reports in Oncological Med. 2017:8201301:6.
Karli R, Kucuk H, Aksoy A, Ayhan E, Unal R. Rifat Malignant Melanoma of the Nasal Cavity Clinical Report Malignant Melanoma of the Nasal Cavity: Our Clinical Experience. J Hard Tissue Biol. 2015;22:279-82.
Wenig BM, Prasad ML, Dulguerov P, Fanburg JC, Kapadia SB, Thomson LD. Neuroectodermal tumors. In: Barnes L, Eveson JW, Reichart P, Sidransky D, editors. WHO classification of tumors. Pathology and Genetics, Head and Neck Tumors. Lyon: IARC Press; 2005: 65-75.