Verrucous carcinoma of the glottis and subglottis: a rare case report

Markandeya Tiwari, Vinson Louis Gonzaga Fernandes, Nina Margarida De Gouveia Pinto, Isha Rajendra Sukhthankar


Verrucous carcinoma is a rare well differentiated squamous cell carcinoma with minimal metastatic potential. Its occurrence in the glottic and subglottic subsets of the larynx is another very rare entity. We highlight a case of an elderly male who was histopathologically diagnosed as verrucous carcinoma of the glottic and subglottic larynx. We shall discuss the clinical presentation, diagnosis, management, prognosis and postoperative follow up of the patient.



Verrucous carcinoma, Larynx, Glottis, Subglottis

Full Text:



Devaney KO, Ferlito A, Rinaldo A, El-Naggar AK, Bames L. Verrucous carcinoma (carcinoma cuniculatum) of the head and neck: What do we know now that we did not know a decade ago? Eur Arch Otorhinolaryngol. 2011;268:477-80.

Maurizi M, Cadoni G, Ottaviani F, Rabitti C, Almadori G. Verrucous squamous cell carcinoma of the larynx: Diagnostic and therapeutic considerations. Eur Arch Otorhinolaryngol. 1996;253:130-5.

Santoro A, Pannone G, Contaldo M, Sanguedolce F, Esposito V, Serpico R, et al. A Troubling Diagnosis of Verrucous Squamous Cell Carcinoma ("the Bad Kind" of Keratosis) and the Need of Clinical and Pathological Correlations: A Review of the Literature with a Case Report. J Skin Cancer. 2011;2011:370605.

Orvidas LJ, Olsen KD, Lewis JE, Suman VJ. Verrucous carcinoma of the larynx: A review of 53 patients. Head Neck. 1998;20:197-203.

Ackerman LV. Verrucous carcinoma of the oral cavity. Surgery. 1948;23(4):670-8.

Aird I, Johnson HD, Lennox B, Stansfeld AG. Epithelioma cuniculatum: a variety of squamous carcinoma peculiar to the foot. Br J Surg. 1954;42(173):245-50.

Murao K, Kubo Y, Fukumoto D, Matsumoto K, Arase S. Verrucous carcinoma of the scalp associated with human papillomavirus type 33. Dermatol Surg. 2005;31(10):1363-5.

Mirbod SM, Ahing SI. Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions. J Can Dent Assoc. 2000;66(6):308-11.

Terada T. Verrucous carcinoma of the skin: a report on 5 Japanese cases. Ann Diagn Pathol. 2011;15(3):175-80.

Huang SH1, Lockwood G, Irish J, Ringash J, Cummings B, Waldron J, et al. Truths and myths about radiotherapy for verrucous carcinoma of larynx. Int J Radiat Oncol Biol Phys. 2009;73(4):1110-5.

Witt RL, Wilson P. Missed opportunity for larynx preservation? Failure to distinguish verrucous and squamous cell carcinoma on microlaryngoscopy and biopsy. J Voice. 2009;23(1):140-2.

Perez CA, Kraus FT, Evans JC, Powers WE. Anaplastic transformation in verrucous carcinoma of the oral cavity after radiation therapy. Radiology. 1966;86(1):108-15.

Walvekar RR, Chaukar DA, Deshpande MS, et al. Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases. Oral Oncol. 2009;45(1):47-51.