Study of association of family history and consanguinity with congenital hearing loss
DOI:
https://doi.org/10.18203/issn.2454-5929.ijohns20160955Keywords:
Congenital, Hearing loss, Family, History, ConsanguinityAbstract
Background: Knowledge about the association of family history and consanguinity with congenital hearing loss is vital in order to prevent occurrence of such morbidity in future generations. The aim of the study was to find the strength of association between family history and consanguinity and congenital hearing loss.
Methods: A case control study was done using 50 congenitally deaf children and 50 children with normal hearing. A detailed history was taken from the parents with regard to family history of hearing loss and consanguinity.
Results: In the case group, 28% children had a family history of hearing loss and in the control group; none had a family history of hearing loss. In the case group, 48% of the children had parents with consanguinity. In the control group, 28% of the children had parents with consanguinity.
Conclusions: Family history and consanguinity play significant role in children having congenital hearing loss. Hence, avoidance of consanguineous marriages and pre-marital genetic counselling can prevent congenital hearing loss.
References
Dhingra PL, Dhingra S. The deaf child in Diseases of ear, nose and throat. 6thed, New Delhi; Elsevier. 2014:115.
Alberti PW. Anatomy and physiology of ear and hearing. In: Occupational exposure to noise: Evaluation, prevention and control. 2001:51-63.
Sujata De, Slie A, Ray C. Investigation and management of the deaf child. In: Scott-Brown's Otorhinolaryngology, Head and Neck Surgery. 7thed, vol 1;London; Hodder Arnold. 2008:853.
Bitner-Glindzicz M. Genetics of Non-Syndromic Deafness. In Paediatric ENT. 1st ed. Springer; New York. 2007:48.
Nagapoornima P, Ramesh A, Srilakshmi, Rao S, Patricia PL, Gore M. Universal hearing screening. Indian J Pediatr. 2007;74:545-9.
Korver AM, Admiraal RJ, Kant SG, Dekker FW, Wever CC, Kunst HP. Causes of permanent childhood hearing impairment. Laryngoscope. 2011;121:409-16.
D'Mello J. High risk register: An economical tool for early identification of hearing loss. Indian J Pediatr. 1995;62:731-5.
Joseph AY, Rasool TJ. High frequency of connexin 26 (GJB2) mutations associated with nonsyndromic hearing loss in the population of Kerala, India. Int J Pediatr Otorhinolaryngol. 2009;73:437-43.
Selvarajan HG, Arunachalam RK, Bellur R, Mandke K, Nagarajan R. Association of family history and consanguinity with permanent hearing impairment. Indian J Otol. 2013;19:62-5.
Zakzouk S. Consanguinity and hearing impairment in developing countries: A custom to be discouraged. J Laryngol Otol. 2002;116:811-6.
Khabori MA, Patton MA. Consanguinity and deafness in Omani children. Int J Audiol. 2008;47:30-3.
Amini SR, Kamali M. Consanguineous marriage among the parents of hearing impaired students in mashhad. Iran Rehabil J. 2010;8:36-9.
Aruchamy L. Clinical Pediatrics. New Delhi: Wolters Kluwer. 2010. Available from: http://www.lwwindia.co.in/book/9788184732221/clinical-pediatrics.aspx. [Last accessed on 2012 Nov 17].
Bittles AH. The Global prevalence of consanguinity. 2009. Available from: http://www.consang.net/index.php/Global_prevalence. [Last accessed on 2012 Dec 7].
Smith RJH. An Eliot Shearer, Michael S
Hildebrand, and Guy Van Camp. Deafness and Hereditary Hearing Loss Overview. Seattle: University of Washington. 2016. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1434/. [Last accessed on 2016 March 04].
Toriello HV, Reardon W, Gorlin RJ, eds. Hereditary Hearing Loss and Its Syndromes. New York: Oxford University Press. 2004.
Van Camp G, Willems PJ, Smith RJ. Nonsyndromic hearing impairment: unparalleled heterogeneity. Am J Hum Genet. 1997;60:758-64.
Green GE, Scott DA, McDonald JM, Woodworth GG, Sheffield VC, Smith RJ. Carrier rates in the Midwestern United States for GJB2 mutations causing inherited deafness. JAMA. 1999;281:2211-6.
Smith RJH, Bale JF, White KR. Sensorineural hearing loss in children. Lancet. 2005;365:879-90.