Fungi in association with chronic bacterial rhinosinusitis; relationship with a synergistic effect: a prospective study

Authors

  • Namit Kant Singh Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Lakshmi Narayan Garg Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Shubhranshu Shekhar Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Naiya Rao Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Chandpreet Kour Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Anshul Singh Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India
  • Hitesh Kuhar Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

DOI:

https://doi.org/10.18203/issn.2454-5929.ijohns20183700

Keywords:

Sinusitis, Fungi, Bacteria, Biofilms, Symbiosis

Abstract

Background: The role of fungi as an etiological factor in the causation of chronic rhinosinusitis remains uncertain. The interaction of Fungi with bacteria can result formation of mixed biofilm which provide symbiotic relationship along with resistance from antimicrobials with an increased severity of symptoms.

Methods: The cases of chronic rhinosinusitis were diagnosed and the grading of the symptom severity was done by visual analog scale in which symptoms of nasal blockage, rhinorrhea or post nasal drip, facial pain/headache, loss of smell, sleep disturbance/ fatigue were taken into consideration and each of the symptoms was graded from 1 to 10.  

Results: A strong association was detected between bacteria and fungi as 37 out of 40 (92.5%) amongst cases and 31 out of 40 (77.5%) amongst controls showed growth of both the organisms. Cases who were detected of having Fungi with Bacteria were having an average score of 8.364 and cases with bacteria alone were having an average score of 6.36. taking into consideration the individual symptom score and analyzing the data, the comparison between cases having both bacteria and fungi and cases with bacteria alone was found to be statistically significant with a p one-tail= 0.010221 and p two-tail= 0.020442.

Conclusions: In chronic rhinosinusitis there is a higher incidence of poly microbial infection, and bacteria along with fungi co-exist with a synergistic effect leading to a higher morbidity.

Author Biographies

Namit Kant Singh, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Associate Professor

Department of E.N.T and Head and Neck Surgery

Maharishi Markandeshwar Institute of Medical Sciences, Mullana

Ambala

Lakshmi Narayan Garg, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Professor

Department of E.N.T and Head and Neck Surgery

Maharishi Markandeshwar Institute of Medical Sciences, Mullana

Ambala

Shubhranshu Shekhar, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Senior Resident

Department of E.N.T and Head and Neck Surgery


Maharishi Markandeshwar Institute of Medical Sciences, Mullana


Ambala

Naiya Rao, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Ex Post Graduate Resident

Department of E.N.T and Head and Neck Surgery


Maharishi Markandeshwar Institute of Medical Sciences, Mullana


Ambala

Chandpreet Kour, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Ex Post Graduate Resident

Department of E.N.T and Head and Neck Surgery


Maharishi Markandeshwar Institute of Medical Sciences, Mullana


Ambala

Anshul Singh, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Post Graduate Resident

Department of E.N.T and Head and Neck Surgery


Maharishi Markandeshwar Institute of Medical Sciences, Mullana


Ambala

Hitesh Kuhar, Department of E.N.T and Head and Neck Surgery, Maharishi Markandeshwar Institute of Medical Sciences, Mullana, Ambala, Haryana, India

Intern

Maharishi Markandeshwar Institute of Medical Sciences, Mullana

Ambala

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Published

2018-08-25

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Original Research Articles