DOI: http://dx.doi.org/10.18203/issn.2454-5929.ijohns20183695

Study of effect of 1% sodium hyaluronate application on tympanic membrane perforation

Dimple Sahni, Bikramjit Singh, K. S. Uppal, Sanjeev Bhagat, Dinesh Sharma, Girish Dogra

Abstract


Background: Topical applications of hyaluronic acid have been found to have beneficial effects on closure of tympanic membrane perforations. The aim of the study was to evaluate the role of 1% sodium hyaluronate in the repair of small or medium sized dry central tympanic membrane perforation and improvement in hearing following closure of tympanic membrane perforation.

Methods: 50 patients with dry central perforation of inflammatory or traumatic origin were taken up. Maximum of 4 applications of 1% sodium hyaluronate were given at weekly intervals. Final mapping for closure of tympanic membrane perforation and hearing assessment was done after 3 months.  

Results: 26 perforations closed completely while 18 perforations showed significant reduction in size. Thus 44 or 88% perforations showed positive response to 1% sodium hyaluronate application. Hearing Improvement was observed on pure tone audiometry with the average hearing gain in patients after complete closure of tympanic membrane perforation was 12.40 dB with p value of 0.001.

Conclusions: Study showed the beneficial effects of 1% sodium hyaluronate application in closure of small and medium size perforations of tympanic membrane perforation and improvement in hearing.

 


Keywords


Hyaluronic acid, Tympanic membrane perforation, Pure tone audiometry, Chemical cautery, Hearing loss

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