Does copper deficiency predispose children to otitis media with effusion?
Keywords:Copper, Otitis media with effusion, Selenium
Background: Both otitis media with effusion (OME) and copper or selenium have been associated to the immune system, hence it could be proposed that cooper and/or selenium deficiency predisposes children to OME through immune cells dysfunction. The aim of this study was to determine the serum levels of Copper and Selenium in an immundeficient-linked disease - OME – in childhood.
Methods: This cross-sectional study was conducted between July 2015 and December 2016 including 80 patients age 1 to 8 years old who were divided into two groups: otitis media with effusion (OME) consisted of 40 patients and the control (n=40). Patients who did not recover after three months conservative treatments were included. Serum levels of Copper and Selenium were measured using graphite furnace atomic absorption spectrometry.
Results: Statistical analysis showed no significant differences regarding age and sex were noted between groups. Patients with OME had significantly lower serum copper levels than the control group (p=0.007). However, there was no statistically significant difference in serum selenium levels between groups. The analysis also showed a significant positive correlation between serum copper level and age (correlation coefficient=0.348, p=0.028), whereas, there was no correlation between the measured selenium level and age.
Conclusions: The results of the present study showed that serum level of copper might play a role on development of otitis media with effusion in childhood.
Zemotti ME, Pawnkar R, Ansotegui I, Badellino H, Croce JS, Hossny E. Otitis media with effusion and atopy: is there a causal relationship? World Allergy Organ J. 2017;10(1):37.
Elicora SS, Ozturk M, Sevinc R, Derin S, Dinc AE, Erdem D. Risk factors for otitis media effusion in children who have adenoid hypertrophia. Int J Pediatr Otorhinolaryngol. 2015;79:374–7 .
Wilson NW, Hogan MB. Otitis media as a presenting complaint in childhood immunodeficiency diseases. Curr Allergy Asthma Rep. 2008;8:519-24.
Talas ZS, Ozdemir I, Yilmaz I et al. The investigation of the antioxidative properties of the novel synthetic organoselenium compounds in some rat tissues. Exp Biol Med. 2008;233:575–9.
Aydoğan F, Taştan E, Aydın E, Senes M, Akgedik S, Berkem R, et al. Antioxidant role of selenium in rats with experimental acute otitis media Indian J Otolaryngol Head Neck Surg. 2013;65:541-7.
Wintergerst ES, Maggini S, Hornig DH. (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab. 2007;51:301–23.
Ross E, Munoz FM, Edem B, Nan C, Jehan F. Failure to thrive: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data. Vaccine. 2017;35:6483–91.
Jone DG, Suttle NF. Some effects of copper deficiency on leukocyte function in sheep and cattle. Res Vet Sci. 1981;31:151–6.
Boyne R, Arthur JR. Effects of selenium and copper deficiency on neutrophil function in cattle. J. Comp. Pathol. 1981;91:271–6.
Jones DG, Suttle NF. The effect of copper deficiency on the resistance of mice to infection with Pasteurella haemolytica. J Comp Pathol. 1983;93:143–9.
Crocker A, Lee C, Aboko-Cole G, Durham C. Interaction of nutrition and infection: effect of copper deficiency on resistance to Trypanosoma lewisi. J Natl Med Assoc. 1992;84:697–706.
Newberne PM, Hunt CE, Young VR. The role of diet and the reticuloendothelial system in the response of rats to Salmonella typhimurium infection. Br J Exp Pathol. 1968;49:448-57.
Smith AD, Botero S, Levander OA. Copper deficiency increases the virulence of amyocarditic and myocarditic strains of cox- sackievirus B3 in mice. J Nutr. 2008;138:849-55.
Scaletti RW, Trammell DS, Smith BA, Harmon RJ. Role of dietary copper in enhancing resistance to Escherichia coli mastitis. J Dairy Sci. 2003;86:1240-9.
Babu U, Failla ML. Respiratory burst and candidacidalac-tivity of peritoneal macrophages are impaired in copper-deficient rats. J Nutr. 1990;120:1692–9.
Babu U, Failla ML. Copper status and function of neutrophils are reversibly depressed in marginally and severely copper-deficientrats. J Nutr. 1990;120:1700 –9.
Torre PM, Harmon RJ, Sordillo LM, Boissonneault GA, Hemken RW, Trammell DS. Modulation of bovine mononuclear cell proliferation and cytokine production by dietary copper insufficiency. J Nutr Immunol. 1995;3:3–20.
Elemraid MA, Mackenzie IJ, Fraser WD, Harper G, Faragher B, Atef Z. A case-control study of nutritional factors associated with chronic sup- purative otitis media in Yemeni children. Eur J Clin Nutr. 2011;65:895-902.
Delesalle C, de Bruijn M, Wilmink S, Vandendriessche H, Mol G, Boshuizen B. White muscle disease in foals: focus on selenium soil content. A case series. BMC Vet Res. 2017;13(1):121.