Does copper deficiency predispose children to otitis media with effusion?


  • Maryam Amizadeh Clinical Research Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
  • Sareh Molaei Moghbeli Clinical Research Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran
  • Hamed Reihani-Kermani Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • Amir Reihani Department of Life science, McMaster University, Hamilton, Ontario, Canada



Copper, Otitis media with effusion, Selenium


Background: Both otitis media with effusion (OME) and copper or selenium have been associated to the immune system, hence it could be proposed that cooper and/or selenium deficiency predisposes children to OME through immune cells dysfunction. The aim of this study was to determine the serum levels of Copper and Selenium in an immundeficient-linked disease - OME – in childhood.

Methods: This cross-sectional study was conducted between July 2015 and December 2016 including 80 patients age 1 to 8 years old who were divided into two groups: otitis media with effusion (OME) consisted of 40 patients and the control (n=40). Patients who did not recover after three months conservative treatments were included. Serum levels of Copper and Selenium were measured using graphite furnace atomic absorption spectrometry.  

Results: Statistical analysis showed no significant differences regarding age and sex were noted between groups. Patients with OME had significantly lower serum copper levels than the control group (p=0.007). However, there was no statistically significant difference in serum selenium levels between groups. The analysis also showed a significant positive correlation between serum copper level and age (correlation coefficient=0.348, p=0.028), whereas, there was no correlation between the measured selenium level and age.

Conclusions: The results of the present study showed that serum level of copper might play a role on development of otitis media with effusion in childhood.


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